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BMI over 30, or over 27 with metabolic risk factors History of weight loss followed by regain Concerns about muscle loss during weight reduction Signs of age-related growth hormone decline Commitment to dietary and exercise optimization alongside peptide use Understanding of research compound status and associated considerations Those specifically concerned about muscle preservation during weight loss make particularly appropriate candidates for the combined protocol

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Oral semaglutide versus subcutaneous liraglutide and placebo in type 2 diabetes (PIONEER 4): a randomized, double-blind, phase 3a trial