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Description

The activity of this enzyme in the ovary could be a double-edged sword: on the one hand, the NADPH-dependent metabolism of DOX into doxorubicinol by CBR1 allows for the subsequent conjugation and excretion of this drug, and in doing so could deplete NADPH levels needed for the regeneration of GSH needed to neutralise ROS

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Molecualr Biology of the Cell

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Characterization of the bifunctional -glutamatecysteine ligase/glutathione synthetase (GshF) of Pasteurella multocida

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Human evidence remains limited

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The EPA plans to extend this testing to include major systems like those in Los Angeles, Chicago, Boston, and Philadelphia by 2026

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