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In Phase 3 TRIUMPH-1 data, nausea was reported in 28.6% of participants taking 4 mg, 38.4% taking 9 mg, and 42.4% taking 12 mg, compared with 14.8% of participants receiving placebo

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Most patients report mild or no nausea by their second or third month of treatment

Teas J, Pino S, Critchley A, Braverman LE (2004) Variability of iodine content in common commercially available edible seaweeds

However, the oxidation and consumption of intracellular GSH coupled with Cdr1p-mediated export of F-GS results in depletion of intracellular GSH, disruption of the redox balance and oxidative stress leading to apoptosis.