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In Group B, the half maximal inhibitory concentration (IC50) for AX is in the range between 101 mM whereas in Group A more than 100 fold lower concentration is needed (Fig

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Variants in FTO (fat-mass and obesity-associated), GLP1R (the receptor every GLP-1 compound targets), MC4R (a satiety and energy-balance receptor), and TCF7L2 (tied to glucose handling and GLP-1 secretion) describe the terrain any compound acts on

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10 th ed: John Wiley & Sons, Inc