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It is also synthesized in skeletal muscle and regulates muscle growth in an autocrine/paracrine fashion[2]

Liensinine (LIEN), as an isoquinoline alkaloid, activates the TAK1/AMPK pathway to reduce PA-induced lipid accumulation and ROS generation in hepatocyte models in vitro , while bidirectionally regulating lipid metabolism-related proteins in HFD-induced mice - downregulating FAS, SCD, and PPAR while upregulating PPAR , UCP2, and CPT-1 (Zhang W

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