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All patients gave a written declaration to which they had provided consent

Statistical Analysis Statistical analysis was performed by parametric one-way analysis of variance (ANOVA), with post-hoc NewmanKeuls test and non-parametric KruskalWallis test and subsequently the MannWhitney U test to compare groups

Among the 16 amino acids, Cys showed the highest antioxidant activity with 870.84 g AEAC/mg, followed by arginine (4.43 g AEAC/mg) and histidine (3.81 g AEAC/mg)

In some embodiments, the otic formulation or composition comprises between about 1% to about 7% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

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