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This mitochondrial failure is the direct biochemical driver of the profound, debilitating fatigue and post-exertional malaise (PEM) that patients experience after even minor physical or cognitive exertion

If the ability to reduce GSSG to GSH is overwhelmed by a high burden of oxidative stress, GSSG can be exported out of cells or react with protein sulphydryl groups to prevent a major shift in the redox equilibrium [11], thereby depleting cellular GSH

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A clinical trial comparing GHK-Cu to Matrixyl 3000 (one of the most popular anti-aging peptide ingredients in skincare) showed GHK-Cu produced a 55.8% reduction in wrinkle volume compared to control and a 31.6% reduction compared to Matrixyl 3000 itself