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The pathogenesis of Huntingtons disease is mainly related to striatal atrophy and neuron loss

GLP-1 receptor agonists: off-label uses including neurodegenerative diseases and substance use disorders

In the brain, SELENOP is primarily expressed in astrocytes, but neurons have also been identified as a source of endogenous SELENOP through the entire brain (Steinbrenner et al., 2006

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Given a previous study showing that GPX4 had decreased activity in NEC, it appears that the elevation of GPX2 in NEC could be a response to oxidative stress