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Freezing semaglutide causes permanent molecular damage that renders the medication completely ineffective

doi:10.2991/jegh.k.201217.001 Heart Disease and Stroke Statistics2023 Update: A Report From the American Heart Association

While the clinical significance remains unclear, women relying on oral contraceptives should be advised about potential interactions and may need to consider additional contraceptive methods or more frequent monitoring to ensure continued effectiveness

The medication was marketed in doses of up to 1mg/weekly under the brand name Ozempic

reversing these effects requires sustained antioxidant support rather than a single dose