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Metabolic dysfunction (and the more severe metabolic syndrome) are exacerbated by modern lifestyle and dietary habits, leading to chronic inflammation and oxidative stress, which further degrade cell functioning

Gut Metabolite TMAO Induces Synaptic Plasticity Deficits by Promoting Endoplasmic Reticulum Stress

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Several lines of evidence indicated that SIRT3 deacetylates long-chain acyl-CoA dehydrogenase (LCAD), a critical enzyme for long-chain FA degradation, and carnitine palmitoyltransferase 2 (CPT2), a key enzyme for FA transfer, to enhance FAO [28,29,30,31]

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