doi:10.1152/physiolgenomics.00064.2001 Castro RE, Ferreira DM, Afonso MB, Borralho PM, Machado MV, Cortez-Pinto H, Rodrigues CM (2013) miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease
This modulation decreases the metabolism of the cardiovascular risk factor phenylalanine, ultimately reducing myocardial collagen deposition, lowering the cardiac weight index, slowing the progression of myocardial fiber thickening and necrosis, and preventing and ameliorating ISO-induced myocardial fibrosis (Du et al., 2022)
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