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3 Multifaceted effects of metformin: understanding its pleiotropic properties Metformin provides hypoglycemic effect through various mechanisms, such as inhibition of gluconeogenesis in the liver, increased glucose uptake in skeletal muscle and hepatocytes, decreased glucose absorption in the gastrointestinal tract (Viollet et al., 2012

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The Journal of Urology

4 The subsequent accumulation of proteoglycan aggregates in the IVD results in cross-linking and accretion of advanced glycation end products, which are not easily scavenged from the disc

doi: 10.1016/j.actbio.2014.06.015