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Further investigations indicated that the age of patients with type 2 diabetes does not affect the glycemic efficacy of oral semaglutide and the presence of upper gastrointestinal disease, or that hepatic impairment did not affect the pharmacokinetics of semaglutide [61]

Absorption and Bioavailability While both forms contain the same active molecule, injectable formulations generally have higher bioavailability since they enter the bloodstream directly, potentially giving them a slight edge in weight-loss magnitude

Constant feeding sessions (hello, cluster feeding)

Specifically, GLP-1s appear to dampen activity in reward-related regions like the nucleus accumbens, which plays a key role in cravings, dopamine release, and conditioned food responses