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2 Establishes GLP-1RAs are engineered to overcome the rapid degradation of native GLP-1 through DPP-4resistant modifications and exposure-extending strategies such as fatty-acid acylation, enabling sustained receptor occupancy

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It is known that keratinocytes regulate the behavior of melanocytes such as proliferation, melanin synthesis and dendrite formation and the ECM also regulates different cell behaviors (Chung et al., 2011)