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Detailed information available from the included articles for each of these biomarkers is provided in Supplementary Table 3

Activation of SIRT increases resistance to OS (Haigis and Sinclair, 2010) through an increase in metabolic pathways responsible for the detoxification of ROS (Salvatori et al., 2017) such as superoxide dismutase 2 (SOD2), isocitrate dehydrogenase 2 (IDH2) and CAT (Tennen and Chua, 2011)

For B12, prolonged use of metformin and acid-suppressing drugs (PPIs, H2 blockers) may reduce absorption of oral B12, which is one reason injectable B12 is considered in select patients

Y.PiccioL.ChildressP.BollmanB.GhoshA.BrandhorstS.et al

Dietary greenhouse gas emissions (GHGE) To estimate greenhouse gas emissions associated with dietary choices, we utilized data from the Food Recall Impacts on the Environment for Nutrition and Dietary Studies (FRIENDS) database