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b This intervention included an initial 8-week low-calorie meal replacement diet (10001200 kcal/day), followed by a transition to a conventional hypocaloric diet (12001800 kcal/day), along with progressive physical activity goals and regular behavioural counselling over a 68-week period c All patients began treatment with open-label semaglutide, starting at 0.25 mg and gradually escalating to 2.4 mg once weekly by week 16, continuing through week 20

These by-products can be bioactive, paracrine, and endocrine regulators 27

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NICE recommends semaglutide alongside a reduced-calorie diet and increased physical activity for eligible adults when it is used within an appropriate specialist weight-management service