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When tirzepatide was combined with intensive lifestyle intervention (structured diet, exercise, and behavioral counseling), participants achieved a total mean weight loss of 26.6%, roughly 64 pounds, over 84 weeks

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Statistical Analysis Propensity-Score Matching To control for potential confounding and ensure comparability between the treatment and control groups, a 1:1 Propensity-Score Matching (PSM) approach was implemented to select patients in the control cohort who were most similar to those in the treatment cohort