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Among them, SUSTAIN-6 and PIONEER-6 were the cardiovascular outcome trials (CVOTs) that studied the primary adverse cardiovascular outcomes (nonfatal stroke, nonfatal myocardial infarction, or death from cardiovascular causes)

Importantly, the C-terminal region of this protein (residues 59197) remains mostly disordered even in the presence of 1 M kF (Crane-Robinson et al., 1976)