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Metabolic dysfunctionassociated steatohepatitis (MASH, formerly nonalcoholic steatohepatitis, NASH) is a major research focus, characterized by excessive hepatic fat accumulation, inflammation, and hepatocellular injury

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Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse diet-induced obesity in mice. Nature Medicine, 25(11), 17611771