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Aged mice (22 months, equivalent to roughly 65 to 70 human years) treated with MOTS-c three times per week doubled their running capacity on treadmill tests

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They stimulate insulin secretion and inhibit the release of glucagon by the beta and alpha cells of the Langerhans islets of the pancreas, thereby reducing postprandial plasma glucose levels.68 They also reduce gastric emptying time and body weight