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A complete overlap of the individual estimated disposition PK parameter value (CL, V c, Q , V p ) distributions, and the expected distributions (based on demographic characteristics) of the parameter values obtained from the s.c./i.v

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The STEP 2 trial (Davies et al., Lancet 2021) specifically enrolled participants with type 2 diabetes, a condition more prevalent during perimenopause due to metabolic changes

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Combined oral contraceptive pills are often used to manage menstrual irregularity and androgen-related symptoms, while metformin is commonly prescribed to address insulin resistance and other metabolic issues ( 13 )