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Distribution, Biosynthesis, and Disease Associations Glutathione is found both intracellularly and in the extracellular matrix, with particularly high levels in: Lung tissue Brain tissue Liver tissue It is synthesized endogenously through a two-step enzymatic pathway involving -glutamylcysteine synthetase and glutathione synthetase

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doi: 10.3389/fneur.2011.00068 35