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10.1155/2019/7861297 106 WangX.ChenX.TangY.WuJ.QinD.YuL.et al (2022a)

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IGF-1 ceiling and pituitary feedback

We showed that inherent anxiety at baseline and elevated expression of the mineralocorticoid receptors (MR) in the hippocampus predisposes to a stress-induced suppression of expression of metabotropic glutamate receptors-2 (mGlu2, a key inhibitor of spontaneous glutamate release) with development of depressive-like behavior via epigenetic mechanisms of histone acetylation [20]