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About the study The present study compared the nutrient intakes of GLP-1RA users to dietary reference intakes (DRI)

52 GLP-1R agonists also regulate gene expression related to cell maturation (pancreatic and duodenal homeobox 1, MAF bZIP transcription factor A, and neuronal differentiation 1, upregulated) and to apoptosis (thioredoxin interacting protein, CASP3, and B-cell lymphoma 2 (Bcl-2) associated X, apoptosis regulator, downregulated)

However, individual responses can vary

Phase 2 data suggest this is offset by improved lipid oxidation and energy expenditure under chronic dosing, though Phase 3 data remain pending