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While the study cannot prove GLP-1 drugs caused low testosterone levels to normalize, it does show a direct correlation, Portillo Canales noted

Dihexa increases dendritic spine density by 40 to 60 percent in treated brain regions, with electrophysiology confirming these new spines form functional synaptic connections

If improved even slightly, that is a positive sign suggesting adaptation is occurring

Obesity has many metabolic consequences, such as type 2 diabetes mellitus (T2D), metabolic dysfunction-associated steatotic liver disease (MASLD), hypercholesterolemia, chronic kidney disease (CKD), cardiovascular disease, and an increased risk of certain types of cancer [2, 3]