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They slow stomach emptying and increase fullness, which reduces appetite and calorie intake, leading to gradual weight loss

FRAT model and when folinic acid is appropriate When FRAT is positive (folate receptor-alpha autoantibodies), the primary problem is transport into the CNS

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The STEP 1 trial showed average weight loss of 14.9% over 68 weeks, with around half of participants losing 15% or more of their body weight