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However, in human systems the outcome of boosting NAD+ is complex and likely involves numerous pathways, from enhanced activity of sirtuins (implicated in longevity and metabolic control) to improved DNA damage repair, all of which are areas of ongoing investigation

The GSH/GSSG ratio in all diamide-treated hearts was significantly lower after diamide, and the decrease in GSH/GSSG was not significantly affected by the addition of 4-ClDzp (Figure 1C)