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Metabolic effects of very-low calorie diet, semaglutide, or combination in individuals with type 2 diabetes mellitus

Schematic of GPCR Bioassay

Studies demonstrate that adequate protein consumption (at least 60-75 grams daily) helps maintain metabolic health while losing weight with GLP-1 receptor agonists

361,362,363 Proton magnetic resonance spectroscopy studies have shown a reduced N-acetylaspartate to creatine ratio in the thalamus and parietal white matter pathways of DPN patients, indicating neuronal dysfunction