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LCs express high levels of VDR, and their phenotype and functional state are profoundly influenced by local concentrations of 1,25(OH)D [139].Studies have shown that 1,25(OH)D significantly suppresses the expression of LC surface maturation markers (such as CD80, CD86, CD40, and MHC II) as well as the chemokine receptor CCR7, thereby reducing their migratory capacity to draining lymph nodes and their ability to activate nave T cells [140]
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Normal cells are mostly unaffected because they do not depend on this FOXO4-p53 interaction for survival and are not already programmed to undergo cell death
Ghasemi-Kasman, M
doi: 10.1016/S1262-3636(10)70472-9 [DOI] [PubMed] [Google Scholar] 134
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