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This finding correlates with those described by Kumar et al., who demonstrated that ER is crucial to enhance OLs production, myelin protein synthesis, remyelination, and axon conduction in EAE mice through the activation of the PI3K/Akt/mTOR signaling pathway, without disturbing inflammation in the corpus callosum or spinal cord (Kumar et al., 2013

Trigonelline, an alkaloid extracted from fenugreek seeds, can reduce hepatic FMO3 activity, inhibit TMA oxidation, and decrease TMAO production, thereby slowing the progression of CKD (Yong et al., 2023) (Figure 9B)

Lee WY, Sim HW, Park HJ

It has been shown to be approximately 10 million times more potent than BDNF (Brain-Derived Neurotrophic Factor) at driving new synapse formation

The IL-6 receptor complex consists of two subunits, IL-6 receptor (IL-6R) and glycoprotein 130 (gp130)