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On the contrary, like in apoptosis, the cell membrane remains intact in eryptotic cells, so that heme, hemoglobin, and other potential erythrocyte-derived DAMPs are preserved from passive cell membrane destruction-associated liberation [78, 91]

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One small randomized controlled trial in 450 pregnant women in West Africa, without specified MTHFR genotype but at high risk for preeclampsia, found that supplementation with 15 mg of riboflavin daily was not effective in preventing the condition (29), but the study was likely underpowered to detect a significant effect

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