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Tremblay-LeMay, R., Rastgoo, N
Patients with a history of liver or kidney disease should also be cautious while using this medication
Rarely, hypersensitivity reactions can occur, for instance, urticaria (hives) or other allergic-type reactions have been reported in isolated cases
It also introduces single-point risks related to logistics and geopolitical factors
Inhibition of COX-2 by NSAIDs blocks PG production at sites of inflammation, whereas inhibition of COX-1 in other tissues (platelets and the gastroduodenal mucosa) leads to common adverse effects of NSAIDs, such as bleeding and gastrointestinal ulceration ( Owing to the adverse effects of NSAIDs and corticosteroids, disease-modifying antirheumatic drugs (DMARDs), a class of immunosuppressive and immunomodulatory agents, are developed to prevent and relieve RA aggression
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