Less common side effects include acid reflux symptoms, injection site irritation, or changes in bowel habits
The increase in plasma TMAO concentration in patients with acute HF indicates a poor 1-year prognosis
Importantly, impaired hepatic metabolic function can compromise carnitine biosynthetic capacity, potentially leading to relative deficiency that may contribute to hepatic lipid accumulation, inflammatory activation, oxidative stress, and insulin resistance
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In obese rat models, VD reduces cardiac TGF-, NF-B activity, and monocyte chemoattractant protein-1 concentration, alleviating inflammation and fibrosis (Ebrahimzadeh et al., 2022)