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(For a discussion of the timing of the cascade typically seen in experimental brain injury models and the consequences of the early, high glycolytic rate resulting in ionic pump disturbance, the reader TABLE 3-1 Initiation of Acute Secondary Events Post-TBI is referred to Hovda et al., 1995.) A series of proteases becomes activated by the increase in calcium, resulting in cytoskeletal damage and further BBB breakdown, cell injury, and generation of free radicals

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11,696,960) regarding the use of N-aminoanthranilic acids for aldehyde imaging