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Rao et al., Cells , 2021)

Diabetes-related complications : Long-term health problems caused by uncontrolled diabetes, including nerve damage, kidney disease, and heart issues

Acknowledgements This work was supported by the Singapore National Medical Research Council (R-174-000-137-275), the Jay and Betty Van Andel Foundation (H Eric XU and Karsten MELCHER), Amway (China) Limited (H Eric XU), and the National Institutes of Health 5R01DK071662-08 (H Eric XU) and GM102545 and GM104212 (Karsten MELCHER)

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Besides the (di)hydroxylation at positions 8, 9 or 10 of the proline ring, hydroxylation at the ergoline ring leading to 12-hydroxy-ergometrine was detected in rats after i.v