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While the IOM had based B12 needs on the amount required to correct hematological parameters for people with pernicious anemia, the EFSA had almost 20 more years of research to draw on, and concluded that the most suitable approach was basing needs on biomarkers (serum B12, holotranscobalamin, MMA, and homocysteine)

Such claims, according to the agency, are in violation of the Federal Food, Drug, and Cosmetic Act, which prohibits the sale of unapproved drugs

doi: 10.2337/dc22-1710

NAD (Nicotinamide Adenine Dinucleotide) is a coenzyme found in every cell of the body, essential for energy production, cellular repair, and healthy brain function

Or does regionality not really matter