semaglutide for hfpef In patients with cardiometabolic #HFpEF, #semaglutide and #tirzepatide reduced the risk of hospitalization heart failure or all-cause mortality compared to sitagliptin, but tirzepatide offered no additional benefit over semaglutide. #ESCCongress Frailty and Effects of Semaglutide

Another class of drugs that acts as a dual GLP-1/GIP (Glucose Dependent Insulinotropic Polypeptide) receptor agonist is called Tirzepatide, and a popular innovator drug of the class is Mounjaro

First, a 2024 study published in JAMA Ophthalmology analyzed cases of NAION (non-arteritic anterior ischemic optic neuropathy) in people using GLP-1 medications

Remarkably, semaglutide markedly improved hepatic steatosis, fibrosis, and immune remodeling in the absence of weight reduction. In a further test, mice lacking LSEC receptors showed no liver improvement on semaglutide even after losing 20% of their body weight

31 In OVX insulin-deficient streptozotocin (STZ) diabetic rats, liraglutide significantly lowered serum CTX-I levels and inhibited osteoclast differentiation

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