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In both the intestinal epithelium and liver, they are rapidly transformed into hydrophilic metabolites through phase II enzymatic reactions such as glucuronidation, sulfation, and methylation, catalyzed by enzymes including uridine 5-diphospho-glucuronosyltransferase, sulfotransferase, and catechol- O -methyltransferase

Inflammation in the gut may also impair the function of enterocytes, the specialized cells in the intestinal lining that produce DAO

The peptide enters circulation immediately via subcutaneous capillary absorption

10.1073/pnas.97.2.571 Proc

Standard glutathione capsules are often broken down by stomach acid and digestive enzymes before they can be absorbed into the bloodstream