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Both may be contraindicated if you have: Personal or family history of medullary thyroid carcinoma, Multiple Endocrine Neoplasia syndrome type 2, history of severe pancreatitis, current pregnancy or plans to become pregnant, or severe kidney disease

Common side effects with topical peptides: Mild irritation or redness: Usually happens when you first start using peptides or if you're using too high a concentration

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International Journal of Cosmetic Science, 10(1), 101108

The data consistently shows measurable changes beginning around week 4 and becoming significant by week 8 to 12