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Impaired methylation reduces SAM-e, directly reducing COMT, HNMT, TPMT, and AS3MT activity

Mult Scler (2016) 22(7):93543

An excellent review which summarizes evidence that the intrinsic and synaptic properties of GABA interneurons seem to be optimized for fast and precise control of electrical signalling in neurons and networks

These effects have led to further clinical trials as well as the popularity of this peptide as a potential performance-enhancing drug