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Retatrutide is an investigational once-weekly triple agonist that simultaneously activates GLP-1, GIP, and glucagon receptors, distinguishing it from approved agents such as semaglutide and tirzepatide

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Recent epidemiological research, including studies analysing electronic health records, has identified associations between GLP-1 agonist use and reduced incidence of depression diagnoses or antidepressant prescriptions

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