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Osteoarthritis remains one of the leading causes of chronic pain and disability globally, says Jay Karri, Assistant Professor of Pain Medicine at the University of Maryland School of Medicine and lead author

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Furthermore, acute exposure of Caco-2 cells to alcohol was associated with reduced Ras-related protein 2 (Rap2) activity, and enhanced myosin light chain kinase (MLCK) activity, changes consistent with impaired JAM-A signalling

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