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Napoli N, Faccio R, Shrestha V, Bucchieri S, Rini GB, Armamento-Villareal R

The treatments enhanced tear secretion compared to controls, indicating better ocular surface hydration

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demonstrated that topical GHK-Cu at concentrations as low as 0.01% stimulated collagen synthesis in human dermal fibroblast cultures, and clinical application of GHK-Cu-containing creams improved skin thickness and elasticity in photoaged skin over 12 weeks [1]

These results reveal the dynamic interplay between the structural states of the CRL4 DET1-COP1 E3 ligase complex and its substrate specific activation mechanism, offering mechanistic insights into ubiquitination regulation and a basis for future studies on E3 ligase dynamics