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Intolerable side effects (heart palpitations on phentermine, nausea on Saxenda, mood changes on Contrave) count

GLP-1 receptor expression in the nervous system GLP-1 receptors are not limited to the pancreas and gut

g = 0.54 [0.90 to 0.18])

This slows down your metabolism, causes fluid retention, increases fat storage, and makes it extremely difficult to lose weight even with calorie restriction and workouts

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