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It should be emphasized that the addition of any antihyperglycemic agent to a patients current insulin therapy has the potential to increase the risk of insulin-induced hypoglycemia, particularly at the start of therapy

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Data extraction and bias assessment were performed independently by multiple reviewers

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Chen W, Ni Y, Pan Y et al (2005) GABA, progesterone and zona pellucida activation of PLA 2 and regulation by MEK-ERK1/2 during acrosomal exocytosis in guinea pig spermatozoa