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Funding This work was supported by a grant from ANR as part of the Investissements dAvenir program (ANR-11-LABX-0002-01)

[2] In DIO mice, 5-Amino-1MQ was reported to reduce body weight and white adipose mass and to lower plasma cholesterol, without a measured change in food intake

This review highlights epidemiology, risk factors, genetics, pathogenesis, clinical manifestations, diagnostic methods, epigenetic mechanisms, and recent therapeutic advances

A word of caution Further analysis showed that the lowest levels occurred among participants whose symptoms were most severe, whose medical histories indicated they were resistant to previous treatments, or whose onset of the disorder occurred early in life