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The findings suggest that treatment selection should be individualized based on specific therapeutic goals, patient risk profiles, and tolerability considerations, though the authors conclude that the lack of direct comparative trials remains a significant limitation in the evidence base

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[13] Burping and gastrointestinal symptoms typically emerge within the first 4-8 weeks of starting semaglutide or after dose increases

Patients with persistent heartburn despite optimal PPI therapy or those with alarm symptoms (difficulty swallowing, weight loss, anemia) should be referred for endoscopic evaluation according to clinical guidelines

These offers follow the recent agreement with the US Administration to expand access to medicines for patients living with obesity and other chronic conditions like diabetes, while lowering prices in the direct-to-patient, self-pay channel in 2026 and today, Novo Nordisk is bringing these prices to consumers months in advance of that commitment