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Patients experiencing significant cold intolerance should undergo thyroid function testing, complete blood count to assess for anemia (including iron studies), vitamin B12 levels (especially if taking metformin), and metabolic panel to evaluate overall health status

Even a single accidental freeze (e.g., the vial was too close to the back wall of the fridge) can cause aggregation

Related to nutritional strategies for lipid balance

AMK, Amikacin