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Vitamin A and immune regulation: role of retinoic acid in gut-associated dendritic cell education, immune protection and tolerance

The principle behind the leaky gut theory is that endogenous (e.g., psychological stress, intestinal inflammation) and exogenous factors (e.g., diet, alcohol intake) can increase intestinal permeability, allowing the entrance of food antigens, commensal or pathogenic bacteria and bacterial components into the lamina propria and later on into the systemic circulation, provoking the systemic inflammation described in different disease conditions

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Huangjia Ruangan Granule (HJRG) is a compound preparation of TCM known for its anti-liver fibrosis properties ( P