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The FDA and EMA have issued specific guidance to encourage sponsors from the medical industry to assess potential DDI [46, 47]

While significant progress has been made in identifying key genetic loci, the role of the immune system in disease initiation and progression, and understanding basic viral mechanisms, critical knowledge gaps remain

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It addresses functional B-vitamin insufficiency, particularly during periods of stress or increased metabolic demand, while avoiding imbalance that can occur when single B vitamins are given in isolation